A functional polymorphism of toll-like receptor 4 is not associated with likelihood or severity of meningococcal disease.

ارتباط پلی‌مورفیسم‌های ژنتیکی پذیرنده شبه Toll 4 (TLR4) و استعداد ابتلا به سل ریوی

  Background & Aim: Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) are the members of the Toll-like receptor family and play important roles in recognition and subsequent immune response against mycobacteria. Two functional polymorphisms for TLR2 (Arg677Trp, C à T Arg753Gln, G à A) and TLR4 (Asp299Gly, A à G Thr399Ile, C à T) genes have been associated with a negative influence on ...

P-225: Gene Variations of Toll-Like Receptor 3 in Endometriosis

Background: Endometriosis is a common gynecologic disorder that is characterized by the ectopic growth of endometrial tissue. Recently, endometriosis has been alternatively described as an immune, genetic and hormonal disease caused by exposure to environmental factors. Toll-like receptor 3 (TLR3) comprises a family of receptors through directly recognizing exogenous and endogenous ligands play...

Author's response to reviews Title: Toll-like receptor 9 polymorphisms are associated with severity variables in a cohort of meningococcal meningitis survivors Authors:

CD14 C-159T and Toll-Like Receptor 4 Asp299Gly Polymorphisms in Surviving Meningococcal Disease Patients

BACKGROUND Carriage of Neisseria meningitidis occurs approximately in 10% of the population, onset of invasive meningococcal disease (IMD) cannot be predicted and differs between ages. It remains unclear, which host factors determine invasion of the bloodstream by the bacteria. Innate immunity has a very important role in the first recognition of invading pathogens. The functional single nucleo...

Clinical Value of Toll Like Receptor 4 and CD14 in Children with Acute Lower Respiratory Tract Infection

Toll like receptors (TLRs) with a myeloid differentiation antigen (CD14) recognize and bind various structures from invading microbes and then trigger cell activation. They initiate a variety of effectors' functions, including cytokine secretion, proliferation, co-stimulation or phagocyte maturation. The aim of this study was to evaluate Toll-like receptor 4 (TLR4) and CD14 expression in childr...